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Plenary Lectures

HT Chang Memorial Lecture

Speaker:
Graham Leon Collingridge
University of Toronto/Mount Sinai Hospital, Canada
Time:
08:30-09:15 Oct. 13
Title:
Hebb synapses: mechanisms, functions and dysregulation in Alzheimer's Disease

Dr. Graham L. Collingridge is a British neuroscientis and professor at the University of Toronto and at the University of Bristol. He is also a senior investigator at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto. Professor Collingridge's research focuses on the mechanisms of synaptic plasticity in health and disease, in particular, understanding synaptic plasticity in molecular terms and how pathological alterations in these processes may lead to major brain disorders, such as Alzheimer's disease. Professor Collingridge was with Professors Tim Bliss and Richard Morris as the first UK scientists to share the Brain Prize, one of the world's most coveted science prizes.

CP Wu Memorial Lecture

Speaker:
Abdel El Manira
Karolinska Institute, Sweden
Time:
08:30-09:15 Oct. 12
Title:
Brain circuits for motor actions

Dr. Abdel El Manira is a Distinguished Professor in Neuroscience at the Karolinska Institute. His laboratory has long been making fundamental contributions to the understanding of the neural control of locomotion. His studies in this area are transforming our view of spinal motor-control systems and setting a new agenda for future research in this area. Professor El Manira is an elected member of the Royal Swedish Academy of Sciences, the Royal Academy of Sciences and Technologies of Morocco, and the Academy of Europe. He is also a member of the Nobel Assembly at the Karolinska Institute.

TCCI Lecture

Speaker:
Trevor W.Robbins
University of Cambridge
Time:
08:30-09:15 Oct. 11
Title:
Neurobehavioural basis of compulsion in OCD and drug addiction

Trevor Robbins was appointed in 1997 as the Professor of Cognitive Neuroscience at the University of Cambridge. He was formerly Professor of Experimental Psychology (and Head of Department) at Cambridge from October 2002-October 2017. He is also Director of the Behavioural and Clinical Neuroscience Institute (BCNI), jointly funded by the Medical Research Council and the Welcome Trust. The mission of the BCNI is to inter-relate basic and clinical research in psychiatry and neurology for such conditions as Parkinson's, Huntington's, and Alzheimer's diseases, frontal lobe injury, schizophrenia, depression, drug addiction and developmental syndromes such as attention deficit/hyperactivity disorder. Trevor's current research is focused on impulsive-compulsive disorders (such as OCD and drug addiction) and fronto-striatal systems of the brain. In 2018 he became an Honorary Professor at Fudan University, Shanghai.

IBRO Lecture

Speaker:
Junying Yuan
Department of Cell Biology, Harvard Medical School
Time:
14:00-14:45 Oct. 12
Title:
Regulation of RIPK1 activation in neurodegenerative diseases associated with aging

Junying Yuan made critical contributions to our understanding of apoptosis and necroptosis, two fundamental mechanisms that regulate the survival and death of mammalian cells. Her Ph.D. work, as a student at the Harvard Medical School and conducted in the laboratory of H. Robert Horvitz at the Massachusetts Institute of Technology, provided the first insight into the mechanism of programmed cell death in the nematode C. elegans. Yuan started her own lab in 1990 at the Cardiovascular Research Center, Massachusetts General Hospital, to test her hypothesis that a similar programmed cell death mechanism might exist in mammalian cells. Her daring hypothesis was proved two years later when her laboratory demonstrated that the mammalian interleukin-1b converting enzyme (later named caspase-1) is a functional homologue of C. elegans cell death gene product Ced-3 (Miura et al. 1993) and inhibition of caspase activation blocks neuronal cell death induced by trophic factor deprivation (Gagliardini et al. 1994). These works provided the first insight into the molecular mechanism that regulates apoptosis in mammalian cells. Subsequently, after her move in 1996 to Department of Cell Biology, Harvard Medical School, Yuan lab discovered necroptosis, a regulated necrotic cell death mechanism, and the role of RIPK1 kinase as a key mediator of necroptosis (Degterev et al. 2005, Degterev et al. 2008). This discovery overturned the traditional dogma that necrosis can only be a form of unregulated passive cell death and demonstrated the possibility of inhibiting necrotic cell death in multiple forms of degenerative and inflammatory human diseases. A small molecule inhibitor of RIPK1 kinase (Nec-1) discovered by Yuan lab is currently in preparation for a human clinical trial targeting neurodegenerative disease.

Plenary Lectures

Speaker:
Haruhiko Bito
University of Tokyo Graduate School of Medicine, Japan
Time:
13:30-14:15 Oct. 13
Title:
Multiplex imaging of neural activity and signaling dynamics

Professor Haruhiko Bito received postdoctoral training at Richard Tsien Laboratory, his main contribution was to analyze the phosphorylation modification of specific proteins in neurons after activation and its relationship with gene expression. Its research direction in the laboratory of Tokyo University is to analyze the mechanism of neuronal signal transduction behind the complex biological processes of the brain, including the identification and mechanism analysis of important mediators, and to develop new techniques for more detailed control and tracking of neuronal activity and the dynamic changes of signal molecules.

Speaker:
Ronald Stanton Duman
Yale University School of Medicine
Time:
14:45-15:30 Oct. 11
Title:
Stress, depression, and rapid-acting antidepressants: remodeling synaptic connections

Studies in Dr. Duman's laboratory are focused on identifying the molecular and cellular adaptations that underlie the actions of antidepressant drugs and stress. This includes adaptations of receptors, signal transduction proteins, gene transcription factors, neurotrophic factors, and regulation of synaptic processes and even birth of new neurons (neurogenesis) in the adult brain. Preclinical and clinical studies support the hypothesis that neuronal atrophy and cell loss in response to stress contribute to mood disorders. Conversely, the therapeutic action of antidepressants may occur in part via blocking or reversing these damaging effects of stress. A variety of molecular approaches combined with cellular and behavioral studies are conducted to elucidate the basis of complex behavioral abnormalities.

CNS-CST Award Lectures

Speaker:
Jiulin Du
Institute of Neuroscience, CAS
Time:
14:00-14:45 Oct. 11
Title:
Mapping whole-brain functional and anatomical connectomics by using larval zebrafish

Dr. Jiulin Du is a senior investigator and deputy director of Institute of Neuroscience (ION), Chinese Academy of Sciences (CAS), and deputy director of CAS Center for Excellence for Brain Science & Intelligence Technology. He obtained B.S. degree from University of Science & Technology of China in 1993 and Ph.D. degree from Shanghai Institute of Physiology, CAS in 1998, and then did postdoc studies at Tokyo University and UC Berkeley. He joined ION at 2006 as a principle investigator. His laboratory has developed some novel innovative in vivo methods for zebrafish research, including intron-based knockin, dopamine release monitoring, and 3-dimensional brain vasculature reconstruction and analysis. His research interests are to study neural mechanisms underlying sensoriomotor transformation and adaptive behavior generation, and molecular mechanisms underlying brain vascular development and its neural regulation.

Speaker:
Xiaoming Li
Zhejiang University
Time:
11:15-12:00 Oct. 13
Title:
Emotion, Affective disorders, and the Underlying Neural circuit

Dr. Xiao-Ming Li is the professor of Zhejiang University and Toronto University. He is a “Changjiang” Scholar Distinguished Professor, "Ten thousand plan" innovation talents of the central committee of the communist party organization department, distinguished young scholars gainer. Now he is the Executive Dean of Zhejiang University School of Medicine, the Executive Director of Institute of Neuroscience of Zhejiang University and the Chair of Department of Neurobiology. In 2003, he graduated from the first military medical university and gained medical doctor's degree. For many years engaged in clinical neurological diseases, teaching and scientific research work, as a research project leader, has a key project of national natural science foundation of China, major research plan integration projects, etc. As the main person, he won the second prize of national natural science, the first prize in the provincial science and technology progress prize, second prize of Chinese medical science, second prize of scientific research findings at colleges and universities award, etc. Prof. Li’ main research interest is to understand the molecular mechanisms underlying the formation, maintenance and regulation of synapses and neural circuits, in identifying targets to develop therapeutic strategies for treating neuropsychiatric disorders including schizophrenia, autism, and epilepsy.

 

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